Definately less complicated where wiring is concerned.
With the LS coils, you need brackets to mount them(they are roughly the size of the OEM coils), you need plug wires and boots as well, which adds to the expense. They use fairly short wires, so you'll need to mount the coils somwhere above the head. Might be able to use universal wires and mount the coils in other areas. Since the LS coils have built-in igniters, the settings in the Haltech are super simple.
Running COPs, you need to run an igniter(unless you find some COPs with built-in igniters. There are some, but i got tired of looking). The setting in the Haltech are much more complicated since the igniters you'll use are not "intelligent". Good thing is that i've already figured out the settings, so thats really a moot point. Just input the info and your done. No plug wires/boots. No worrying about mounting coils and such. Also a weight savings. The COP's used with the Haltech will offer a little better spark at higher revs(vs COPs used with the stk v-max ignition) due to the sequential firing(non wasted spark), which will allow a longer charge time for the coils.
Multiple sparks are good, but are only used at lower rpms. All the MSD setups revert to single spark at 5K or so IIRC. No benift and not enough time at the higher revs. IMO, the multiple sparks are not as benificial with EFI as it is with carbs. The multiple sparks help to complete the burn in the chamber. If the fuel is atomized well(as it is with EFI, especially with Sequential EFI), the mixture burns VERY efficentially.