It will be a pain but entirely possible. You have to remove the chrome covers to get access to the manifold plugs and once that is done the access to the adusting screws is very simple. They don't take much to see a big change.
Also, unless you are using a restrictor the needle will bounce quite a bit. You can partially pinch off the line but that adjustment has to be reset as you go too. This comment may not make sense until you get started in your adjustments.
I use an expensive meter to do all my adjusting but there are quite a few reasonably priced gauge sets out there.
Sean