I've got 3 Vizios myself. Their pictures are amazing when tuned correctly they and they are a very good value.
Depending on the series they have a few different menus options. My first recommendation would be to turn off everything in the Picture Advanced Tab.
If you have a setting in the Advanced tab called "Real Cinema Mode" make sure that is off as well, that causes the Soap Opera effect which is very annoying IMO.
If you post the model Number I could give you more specific information on settings.