Here's my expeirence with opening up the vboost full time, this is backed up by a permanently mounted wideband air fuel guage.
A carb is a venturi driven thing.
The faster the flow the greater the suction created to pull fuel through the jets. The faster the flow the more fuel is pulled out in to the intake stream.
An engine is a positive displacement air pump, it is going to move a fixed amount of air no matter what you do to it, exhaust and intake changes only change the amount of vaccum or pressure in these areas as the engine moves air, admittedly changing the density of the air entering the combustion cycle, but not to a huge degree.
Opening up both carbs to an intake stroke only slows down the velocity of the air through the carbs, since the same amount of air is now flowing through two carbs instead of one carb, since this air is being "sucked on" by the vaccum created between the piston and the slide not as severely then the charge will be slightly more dense. But not times two as compared to one carb.
This slower moving air has less "pull" on the jets and pulls less fuel through each carb; thereby pretty much resulting in about the same a/f ratio charge in a slower slower moving mass of air.
I've seen no significant change in a/f ratio with the vboost open and making no other changes, nor does it seem to make any significant performance difference in my 1/4 mile times.; maybe slightly.,
I tend to call myth on vboost open making it richer......
I will say having it open all the time decreases bottom end throttle response, but not significantly. Seat of the pants tells me that it is stronger in the midrange area where the Vboost is starting to think about opening on a normal Vmax, but I've seen no affect on a/f ratio.....
This is the same principle that would apply to a street rod that has way to big a carb, you can tune it to the correct a/f ratios across the board but the throttle response down low is gonna suck.