I have had all 3-Ford, Dodge, & Chevy/GMC over the years. I had a Dodge 3/4 ton 8' bed Prospector edition like KJ's but no 4x4 & mine was blue. I bought from my friend who bought it new. I owned it for about 10 years, it had a 318 cu.in. engine & auto tranny/ loaded. It only got about 13 mpg but it towed like a dream, I only towed utility trailers w/it, no car trailers or heavy construction equip. I've had Ford p/u's & vans for 20+ years, inline 6's & a 351 Windsor, no-outstanding fuel economy but they worked well over the long haul. No recent Fords.
I had a 8' bed GMC 1500 V6 p/u before my current p/u. It got crummy mileage but it didn't require much for repairs over the ~10 years I had it. I bought it from a co-worker, who bought it new. It would do about 78 mph, tops. I put a ton in the bed and it hauled it OK, not that I would make a practice of it.
Now I have a GMC Canyon crew cab I bought new, inline 5 cyl & 5500 lb. tow capacity, much more-fun as a daily driver than any of the others & it gets about 20-21 averaging ~70 mph cruising, and about 23 if I hold speeds down to 60 mph. I don't really need a full-size truck, and expect to hit retirement in it several years away.
You're always gonna take a beating on a new vehicle after 50K mi or 3 years, so if you want to drive it for many years, consider an aftermarket extended insurance plan. I usually wouldn't buy one, but my credit union made it a good deal buying new, and I don't have to worry about bills for 5 years/100K miles from the factory on major drivetrain repairs, and the aftermarket coverage covers everything-else. I've had two minor wiring electrical repairs due to shorts in 4 years/42K mi. and I originally thought to sell it after about this timeframe, but it's been good and I have decided to keep it longer.
If the truck fits what you need it to-do, buy it and enjoy it, and just sell it before the warranty expires if you aren't happy w/it. Mark's F150 Ecoboost sounds like a great truck. A lot of my firefighter friends bought Dodge Cummins p/u's and like them.